A peripherally acting antitussive agent inhibits the citric acid-induced cough reflex in conscious guinea pigs but not the cough reflex induced by electrical stimulation of the afferent superior laryngeal nerve in anesthetized guinea pigs (ED50s 5.5 and 20 mg/kg respectively) prevents BALF eosinophil and neutrophil infiltration in an ovalbumin-sensitized guinea pig model of allergic airway inflammation inhibits increases in tracheal and bronchial plasma exudation induced by cigarette smoke in anesthetized guinea pigs at 30 mg/kg